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  • During normal growth, the neural cell adhesion molecule N-CAM changes on the cell-surface from a sialic acid-rich embryonic, or E form, to several adult, or A forms which have less sialic acid (E-to-A conversion).
  • Received his medical training on the University of Cincinnati and accomplished his Psychiatry Residency and a Fellowship in Geriatric Psychiatry at Yale University School of Medicine.

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The price of E-to-A conversion and the proportions of the totally different A types synthesized in vitro have been just like these observed for the tissues in vivo at comparable times. These results suggest that the publish translational processing in vitro was much like that in vivo. The information were according to the chance that the rise in synthesis of A varieties occurred either in cells that had beforehand synthesized E varieties or in a distinct population of cells that already synthesized A varieties. In pulse-chase experiments, the E form of N-CAM that was synthesized through the first day after explantation persisted as E type for a number of days, at times when newly synthesized N-CAM was predominantly in A types.

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Data that is available includes informati… The neural cell adhesion molecule (N-CAM) inhibits proliferation in major cultures of rat astrocytes. The mechanism of binding of neural cell adhesion molecules.

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